In a genetic algorithm, the order of the genes on a chromosome can have a significant effect on the performance (capacity to generate adaptation) of the genetic algorithm, where two or more genes interact to produce highly fit individuals. If we have a chromosome length of $100$ and genes $A$ and $B$ interact, then having them next to each other is strongly preferable than having them at opposing ends of the chromosome. In the former case, the probability of crossover breaking the genes apart is $1$ in $100$, and in the latter it is one.
What mechanisms have been tried to optimise the order of genes on a chromosome, so that interacting genes are best protected from crossover? Is it even possible?
I've asked at Biology SE if there exists any known biological mechanism which is responsible for such a possible order of the genes on a chromosome.