Hardware comes in two forms, basically: immutable, such as RAM, and mutable, such as FPGAs.
In animals, neurological connections gain in strength by changing the physical structure of the brain. This is analogous to FPGAs whereby signal strength is increased by changing the pathways themselves.
If we achieve sentience using mutable hardware (e.g., neuromemristive systems), will it be possible to make a copy of that "brain" and its active state?
For this question, assume that the brain is how the hardware has "reconfigured" [or etched, if you will] its pathways to strengthen them and the brain's state is captured by how electrons are physically flowing throughout those pathways.