At risk of seeming out-of-scope, I think it's worth mentioning there may be a case that human vs. AI play of serious games games, such as Chess and Go, represents the "deepest" level of human/AI interaction to date. (Game theory is also important because it underlies all optimization, including, I have no doubt, expanding and optimizing AI-to-human interaction.)
I bring this up because in terms of human-to-computer interaction, I doubt there is a more effective means of engagement than computer games, whether "serious" or otherwise. Thus you might find it useful to look at the concept of Gamification, which naturally lends itself to the type of multisensory input and output you're interested in:
"Gamification can improve an individual's ability to comprehend digital content"